What we know about Urinary Tract Infections

Urinary tract infections (UTIs) are common presentations in general practice. The condition mainly affects females. More than 50% of woman have at least one episode of UTI in their lifetime. Diagnosis of this is usually based on symptoms including dysuria (painful urination), frequency and urgency. Women visiting their GP with symptoms of a UTI are often treated with antibiotics before the UTI is confirmed by testing a urine sample in the laboratory.

Why is the SATIN study important?

Uncomplicated UTIs are often self-limiting and do not require antibiotics. In the SATIN study we want to examine whether initial treatment of UTI symptoms with pain relief (ibuprofen) can be equally helpful as antibiotic treatment.

Why stop antibiotic overuse?

Antibiotic use results in antimicrobial resistance or AMR. AMR happens when organisms that cause infection no longer respond to antibiotics that previously were effective to treat the infection. With the global spread of antimicrobial resistance and a lack of new antibiotics being discovered, we need to be more careful with the use of our antibiotics and explore alternatives. Because healthy adults can often recover from a UTI without antibiotics, this may present an opportunity to avoid antibiotic treatment.

Study and recruitment

The study will be carried out in general practices in Ireland. A total of 460 patient across a maximum of 20 practices with be invited to participate in the SATIN study.

Who can take part? 

Women presenting with symptoms of UTI will be asked by to participate when they visit their GP. Patient will be screened using inclusion and exclusion criteria. Patients will receive their treatment and their symptoms will be tracked with a smartphone app. A back-up treatment will be available in case the symptoms do not improve or worsen during or after the 3 day trial treatment.

What does participation involve?

The GP or practice nurse will give the patient all the information on the SATIN study and answer any questions. If the patient decides to participate, the GP or practice nurse will check all the in- and exclusion criteria, collect a urine sample and download the SATIN app on the patient’s smartphone before giving the medication.

The SATIN app will notify the patient twice a day to fill in questions on how they are feeling. Four days after visiting their GP, the patient will receive a phone call from the research nurse to make sure she is getting better and that her symptoms have improved. If the patient’s symptoms worsen or do not improve they can go back to their GP and will be given a different treatment. All treatment received in relation to the study is free. After day 28 the patient will receive a final phone call to finalise the study.

For more information

Researchers at the National University of Ireland, Galway are running this study and it is funded through the HRB Primary Care CTNI.

For more information on the SATIN study please email the SATIN team.